摘要
目的：研究ＺＧ对烧伤后肠道免疫功能的调节。方法：４０％体表面积（ＴＢＳＡ）Ⅲ度烫伤大鼠灌喂复方紫归（ＺＧ）３ｇ／ｋｇ，２／ｄ，共３ｄ（ＺＧ组），灌喂０．９％生理盐水８ｍｌ／ｋｇ，２／ｄ，共３ｄ（对照组）。结果：ＺＧ组肠道内容物ＩｇＡ含量明显高于对照组（Ｐ＜０．０５）；ＺＧ组肠固有层ＣＤ３＋Ｔ淋巴细胞活性明显增强（Ｐ＜０．０５）；ＺＧ组血浆ＬＰＳ、ＭＤＡ明显低于对照组（Ｐ＜０．０５）。结论：复方紫归对烫伤大鼠肠道免疫功能有一定的保护作用，可减轻肠道缺血再灌注损伤和肠源性内毒素血症。
Objective: In ordr to protect the intestinal immunobarrier, Zigui granule (ZG) a complex of Chinese herbs was used to treat the burned rats.Methods:The burned rats were randomly divided into two groups:(1)ZG treated group feded with ZG: (2)control group: feded with 0.9% salime. Results:The levels of IgA in the intestinal content and the number of CD3 T lymphocytes in the lamina propria of the ZG groups were significantly increase (P<0.05), and the levels of plasma MDA and LPS were significantly lower than those of the control group (P<0.05).Conclusion:The results indicate that ZG may protect the inteastinal immunobarrier and prevent gutderived endotoxemia after burn injury.
出处
《军医进修学院学报》
CAS
1998年第1期21-22,共2页
Academic Journal of Pla Postgraduate Medical School
基金
"八五"军队医药卫生科研基金
关键词
烧伤
复方紫归
肠道免疫功能
bats
burns
Tlymphocytes
intestines/immunology
