摘要
为给临床上利用钛质听骨行鼓室成形术提供客观依据，将金属钛环按不同时间组分别植入30只豚鼠的中耳腔嵌于锤骨头上，对中、内耳组织结构进行光镜和扫描电镜观察，并检测动物的血液生化指标、鼠毛中钛元素的含量和听阈的改变。结果表明，钛环植入前后动物的肝肾功能及鼠毛中钛元素的含量均无明显的变化。10d和1个月组中耳粘膜有血迹和少量的炎性细胞浸润；扫描电镜观察纤毛结构紊乱，随时间推移逐渐恢复正常。植入前后相比，ABR阈值无明显差异。提示钛金属对豚鼠机体功能及中、内耳组织生物相容性均良好，无毒副作用。
In order to supply full objective basis about tympanoplasty with titanium, 30 middle ear caves of guinea-pigs were implanted titanium ring in accordance with different time groups. Both before and after titanium ring were implanted, the guinea-pigs were detected in biochemical criterion of blood, titanium content of the hair, the changing of auditory threshold,tissue structural of middle ear and inner ear by energy spectrometry, electro-physiology,microscopy and scanning electron microscopy. The results showed that function of hepatorenal and titanium content of hair haven't signifcant change between pre-and postimplantation of titanium ring. Only 10 days group, it appeared the rising of auditory threshold and inverting of cilia by ABR and scanning electron microscopy. In 10 days and 1 month groups, there were blood stain and inflammatory cells under mucosa. The results suggested that titanium is good biocompatibility and no toxic for organism and mucosa.
出处
《临床耳鼻咽喉科杂志》
CSCD
1998年第3期134-136,共3页
Journal of Clinical Otorhinolaryngology
