摘要
目的:考察注射用加替沙星与注射用头孢美唑分别在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在室温(20±1)℃条件下,分别观察及测定8h内配伍液的外观、pH值及紫外吸收光谱的变化,并用紫外双波长分光光度法测定加替沙星与头孢美唑钠的含量。结果:2药配伍后,8h内的外观、pH值、含量及峰形均无明显变化。结论:注射用加替沙星与注射用头孢美唑可在0.9%氯化钠注射液或5%葡萄糖注射液中配伍应用。
OBJECTIVE： To study the compatible stability of gatifloxacin for injection with cefmetazole for injection in 0.9% sodium chloride injection versus in 5% glucose injection. METHODS： The changes in appearance and pH value and UV absorption spectra for the mixture of gatifloxacin for injection with cefmetazole for injection at room temperature （20 ± 1）℃ with 8 hours were observed, and the contents of gatifloxacin and cefmetazole were determined by dual ultraviolet spectrophotometry. RESULTS： No marked change was noted for the mixture within 8 hours in appearance, pH value, contents and UV peak shape. CONCLUSION： Gatifloxaein for injection is compatible with eefmetazole for injection in 0.9% sodium chloride injection or 5% glucose injection.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第14期1077-1079,共3页
China Pharmacy
基金
河北省医学科学研究重点课题(04177)
关键词
加替沙星
头孢美唑
配伍
稳定性
Gatifloxacin
Cefmetazole
Combination
Stability
