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尖锐湿疣初发患者外周血单核细胞Toll样受体3、4、9的表达 被引量:4

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摘要 Toll样受体(Toll—like receptors,TLR)是天然免疫中重要的模式识别受体,通过识别不同病原体的PAMP,引发信号转导,导致多种炎症介质的释放,并最终激活获得性免疫系统,在连接固有免疫与特异性免疫的过程中发挥着重要的桥梁作用Ⅲ。为了探讨TLRs在抗人乳头瘤病毒(HPV)感染免疫反应中的作用,我们检测34例尖锐湿疣初发患者外周血CD14^+单核细胞TLR3、TLR4和TLR9的表达,报道如下。
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2009年第5期350-350,共1页 Chinese Journal of Dermatology
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参考文献5

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同被引文献84

  • 1钱起丰,卢创林,张明霞.复发性生殖器疱疹患者外周血CD4^+CD25^+Foxp3^+调节性T细胞的检测[J].中华皮肤科杂志,2006,39(12):695-698. 被引量:11
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  • 6Takeda K,Kaisho T,Akira S.Toll-like receptors.Annu Rev Immunol,2003,21:335-376.
  • 7张振楷.带状疱疹//赵辨.临床皮肤病学.3版.南京:江苏科学技术出版社,2003:300-303.
  • 8Latz E,Schoenemeyer A,Visintin A,et al.TLR9 signals after translocating from the ER to CpG DNA in the lysosome.Nat Immunol,2004,5(2):190-198.
  • 9Hochrein H,Schlatter B,O'Keeffe M,et al.Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and-independent pathways.Proc Natl Acad Sci U S A,2004,101(31):11416-11421.
  • 10Lund J,Sato A,Akira S,et al.Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells.J Exp Med,2003,198(3):513-520.

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