摘要
目的探讨12例临床表现酷似假性湿疣的HPV感染的临床及HPV分型特点。方法检测12例有非婚性接触史临床表现为外阴假性湿疣的女患者，以反向杂交法检测活检或局部刮除物中HPV核酸扩增并分型。结果12例HPV全部阳性，12例患者中共查出13种HPV亚型，其中3种低危型11、42、43，10种高危型16、18、31、33、35、39、51、52、58、59。每例患者至少有1种以上高危HPV亚型。4例患者为1种HPV亚型的感染，6例患者为2种HPV亚型的感染，另有两例分别有3或4种HPV亚型的感染。结论在临床表现为假性湿疣患者中有可能包含高危型HPV的感染。
Objective To investigate the clinical features and human papillomavirus （HPV） types in 12 cases of HPV infection characterized by pseudocondyloma of vulvae. Methods Twelve women, who had a history of sexual behavior with non-spouses and presented with pseudocondyloma of vulvae, were included in this study. Tissue specimens were scraped or resected from the lesions of pseudocondyloma of vulvae. PCR-based reverse hybridization assay was performed to determine the genotypes of HPV. Results All the 12 specimens were HPV positive. The reverse hybridization assay generated 13 subgenotypes of HPV, including 3 low-risk genotypes （11, 42 and 43） and 10 high-risk gcnotypes （16, 18, 31, 33, 35, 39, 51, 52, 58 and 59）. All the patients were found to be infected by at least one high-risk genotype. Of the 12 patients, 4 were infected by single type of HPV, 6 by 2 types of HPV, and 2 by 3 or 4 genotypcs of HPV. Conclusion The patients characterized by pseudocondyloma of vulvae may suffer from high-risk HPV infection.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2009年第5期303-304,共2页
Chinese Journal of Dermatology
关键词
假性湿疣
尖锐湿疣
人乳头瘤病毒
Pseudocondyloma of vulvae
Condyloma acuminata
Human papillomavirus
