摘要
目的:探讨肝炎后肝硬化(posthepatitic cirrhosis,PHC)患者血清中细胞因子的水平变化及其与肝功能的关系。方法:采用ELISA法测定58例PHC患者和35例健康者血清细胞因子IL-6、IL-8、TNF-a的水平。同时将肝硬化患者按Child-Pugh肝功能分级标准分成A、B、C三组。结果:肝硬化组IL-6、IL-8、TNF-a的水平明显高于对照组,差异有统计学意义(P<0.01);Child-PughA、B、C三级的IL-6、IL-8、TNF-a水平依次递增,且各级间差异有统计学意义(P<0.01)。结论:随着IL-6、IL-8、TNF-a血清水平的升高而肝损伤程度加重,采用IL-6、IL-8、TNF-a作为临床判断肝脏损害程度的指标具有较好的临床参考价值。
Objective：To explore the serum levels of cytokines of patients with posthepatitil cirrhosis （ HPC ）and the relationship between the cytokines and liver function. Method：Using ELISA technique to measure the serum levels of IL- 6,IL- 8,TNF-α in 58 patients with posthepatitic cirrhosis（ PHC ）and 35 healthy peoples. The patients with postbepatitie cirrhosis （PHC） were classified by A,B,C groups according to the standard of child - pugh. Result： The serum levels of IL - 6,IL - 8 and TNF -α of natients with PHC were significantly higher than those in healthy control group （P 〈 0.01 ）. The serum levels of IL -6,IL -8 and TNF - α of Child - Pugh A,B,C groups were significantly higher than those in healthy groups. Conclusion ：With the increase of the serum levels of IL - 6, IL - 8 and TNF -α, liver damage was aggravated. which indicated that there is an impediment in immune function and it is closely related to liver function. So it is of clinically value to adopt the serum levels of IL - 6, IL - 8 and TNF - α as an indicator to determine the degree to liver damage.
出处
《河北医学》
CAS
2009年第5期564-566,共3页
Hebei Medicine
