摘要
目的探讨血清肌酸激酶(CK)水平与输卵管妊娠病理类型的关系。方法2007年10月至2008年11月在长沙市第八医院就诊的输卵管妊娠患者,采用NAC激活,IFCC法,测定20例破裂型输卵管妊娠患者和26例未破裂型输卵管妊娠患者的血清CK水平。结果破裂型输卵管妊娠血清CK水平为(139.36±33.68)U/L,高于未破裂型输卵管妊娠(108.07±19.02)U/L,差异有统计学意义(P<0.01)。输卵管间质部妊娠血清CK水平(187.80±8.96)U/L高于峡部妊娠(148.37±12.64)U/L,又高于输卵管壶腹部妊娠(108.77±21.75)U/L,两两比较差异有统计学意义(P<0.05〉。以CK活性120U/L作为界值,预测输卵管妊娠破裂的灵敏度为80.0%,特异度为76.9%,阳性预测值72.7%,阴性预测值83.3%。结论测定血清肌酸激酶可用于破裂型和未破裂型输卵管妊娠的鉴别诊断,对预测输卵管妊娠破裂及选择合适的治疗方式有临床价值。
Objective To investigate the relationship between serum creatine kinase level and histopathological types of tubal ectopic pregnancy. Methods Serum creatine kinase level was determined by N - acetyl cysteine （NAC） activation of IFCC method in 20 patients with ruptured tubal pregnancies and 26 patients with unruptured tubal pregnancies that were treated in the eighth people＇ s hospital of Changsha from october, 2007 to november, 2008. Results The mean levels of serum creatine kinase in patients with ruptured tubal pregnancies were significantly higher than that in those with unruptured tubal pregnancies （ 139. 36 ± 33.68 U/ L vs 108.07 ± 19.02 U/ L, P 〈 0. 01 ） . Creatine kinase levels were higher in interstitial tubal pregnancies than that in isthmic pregnancies and ampullary pregnancies （ 187.80 ± 8.96 U/L vs 148.37 ± 12. 64U/ L vs 108. 77 ± 21.75 U/L, P 〈 0. 05） . The deferences of relative comparison were significantly. The cutoff value of creatine kinase to be used for the prediction of rupture of tubal pregnancy was 120 U/L, which resulted in a sensitivity of 80. 0% and specificity of 76. 9 %. The positive and negative predictive value were 72. 7% and 83.3% ,respectively. Conclusion Serum creatine kinase determination may help in discriminating ruptured tubal pregnancies from unruptured ones, it also has clinic value in predicting rupture of tubal pregnancy and selecting suitable treatment mode.
出处
《中国实用医药》
2009年第12期15-16,共2页
China Practical Medicine
关键词
输卵管妊娠
肌酸激酶
病理类型
Tubal pregnancy
Creatine kinase
Pathologic type
