摘要
目的:探讨甲氨蝶呤(MTX)联合米非司酮治疗异位妊娠的临床疗效。方法:对94例异位妊娠患者采用保守药物治疗的临床资料进行了回顾性分析,并将其分成对照和治疗两组。其中对照组42例患者采用单项注射甲氨蝶呤(MTX)治疗;治疗组52例患者采用MTX注射并联合米非司酮治疗。结果:治疗组患者有效率为92.3%,明显高于对照组76%,差异有显著意义(P<0.05),治疗组较对照组疗程更短。两组比较,治疗组β-HCG降至正常范围的时间明显缩短,差异有显著性(P<0.05),且治疗组与对照组相比并不增加治疗的不良反应。结论:甲氨蝶呤联合米非司酮治疗异位妊娠成功率高、疗程短、安全可靠、经济、简便、无明显不良反应,而且易被患者接受,并可以保留生育能力。值得各基层医院临床推广。
Objective： To explore the significance of clinical effect on combining Methotrexate（MTX） with Mifepristone in treating ectopic pregnancy. Methods： An retrospective study on 94 women with conservative treatment in ectopic pregnancy were investigated, 52 cases was combined MTX and Mifepristone treatment（ treatment group） ,42 cases was treated using intramuscular MTX only （ control group）. Results ： The successful rate of the treatment group was significantly higher than that of the control group（P 〈0.05 ）. The time of blood β- HCG decreasing to normal level was （ 14.8 ± 6.3 ） d and the average time in hospital of the treatment group was （ 17.6± 5.0） d,which were both significantly less than those of the control group （ P 〈 0.05 ）. The treatment group did not add the side effect compare with the control group. Conclusions ： The combination treatment of Methotrexate and Mifepristone is a simple, effective, highly successful method with a short period of treatment and no more side effects. What＇s more, it is acceptable for preserving reproductive ability and worth generalizing in primary hospitals.
关键词
异位妊娠
甲氨蝶呤
米非司酮
药物疗法
Ectopic pregnancy
MT
Mifepristone
Conservative treatment
