摘要
烟苄酯合成工艺的研究及改进对实现其国产化具有积极意义。在实验中,将4-甲基苯乙酮还原成4-甲基-α-苯乙醇,将烟酸制成烟酰氯,两者再酯化合成烟苄酯。经正交实验,对上述合成工艺进行了优化。产品经纯化后,纯度达98%以上,收率可达70%。
Study on the synthesis of 1-（4-Methylphenyl） ethylnicotinate is of positive significance for realizing its domestical production. In this experiment, 4-methyl acetophenone was reduced to 1-（4-Methylphenyl） ethanol, and nicotinoyl chloride was prepared by nicotinic acid, then 1 -（4-Methylphenyl） ethylnicotinate was synthesized from 1 -（4-Methylphenyl） ethanol and nicotinoyl chloride. Though orthogonal experiment, synthesis technology had been optimized. The yield reaches 70%, the purity of product is above 98%.
出处
《四川理工学院学报（自然科学版）》
CAS
2009年第2期97-99,共3页
Journal of Sichuan University of Science & Engineering(Natural Science Edition)
关键词
烟酸
对甲基苯乙酮
硼氢化钠
烟苄酯
nicotinic acid
1-methyl-4-acetylbenzene
sodium borohydride
1-（4-Methylphenyl）ethylnicotinate
