摘要
目的观察合并高血压的脑卒中并发稳定期慢性阻塞性肺疾病患者应用血管紧张素转换酶抑制剂(ACEI)类降压药对其预防吸入性肺炎的影响。方法将120例合并高血压非昏迷且年龄≥60岁的脑卒中伴稳定期慢性阻塞性肺疾病患者分为ACEI组和对照组,ACEI组患者应用ACEI类降压药(卡托普利)治疗,对照组应用其它类型的降压药,观察两组在住院期间吸入性肺炎等并发症的发生情况。结果在住院期间ACEI组有4例患者(6.7%)并发吸入性肺炎,而对照组有13例患者(21.7%)合并吸入性肺炎,两组相比差异有统计学意义(P<0.05)。ACEI组有11例(18.3%)患者出现不同程度咳嗽,其中4例因持续性干咳而停药。ACEI组住院期间患者死亡率为3.3%,而对照组患者死亡率为5%,两组差异无统计学意义。结论预防性应用ACEI类降压药,可降低合并高血压非昏迷老年脑卒中伴稳定期慢性阻塞性肺疾病患者并发吸入性肺炎的发生率。
Objective To investigate the effect of angiotensin-converting enzyme inhibitors on incidence of aspiratory pneumonia in elderly hypertensive stroke patients with chronic obstructive pulmonary disease. Method 120 stroke patients over age 60 were divided into ACEI group and control group. The aspiratory pneumonia and clinical effect of treatment were compared between two groups. Result Aspiratory pneumonia in ACEI group was significantly lower than in control group （P〈0.05）. Cough occurred in 11 （18.3%）patients and ACEI has to be stopped in 4 of them. No difference of death rates were found within ACEI group and control group. Conclusion ACE inhibitors can reduce the risk of aspiratory pneumonia and has ability to prevent the aspiratory pneumonia in elderly hypertensive stroke patients with chronic obstructive pulmonary disease.
出处
《热带医学杂志》
CAS
2009年第4期422-424,共3页
Journal of Tropical Medicine
关键词
脑卒中
慢性阻塞性肺疾病
血管紧张素转换酶抑制剂
吸入性肺炎
stroke
chronic obstructive pulmonary disease
angiotensin-converting enzyme inhibitors
aspiratory pneumonia
