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真菌表观遗传学研究进展 被引量：3

Recent Advances on Fungal Epigentics
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摘要 自1986年在粗糙脉孢菌(Neurospora crassa)中首次发现真菌所特有的真核生物基因沉默机制重复序列诱导的点突变(repeat-induced point mutation,RIP)以来,在真菌中又相继发现了减数分裂前诱导的甲基化(methylation induced premeiotically,MIP)、压制(quelling)和非配对DNA介导的减数分裂沉默(meiotic silencing by unpaired DNA,MSUD)等RNA沉默现象。另外,在真菌中也发现存在有与高等动植物中相似的DNA甲基化、RNA干扰和染色质重塑等表观遗传现象。对真菌表观遗传学的深入研究不仅丰富和推动了真核生物表观遗传学的内容和发展,也极大地促进了真菌系统进化的研究和转基因沉默问题的解决。 Since the repeat-induced point mutation （RIP）, a gene silencing mechanisms in Neurospora crassa, was discovered in 1986, methylation induced premeiotically （MIP）, quelling, and meiotic silencing by unpaired DNA （MSUD） had been found in fungi one after another. Furthermore, DNA methylation, RNA interference, and chromatin remodeling, similar gene silencing mechanisms to higher plants and animals, were sought in a number of fungi. Studying fungal epigentics in depth can enrich and promote our knowledge on eukaryotic epigentics, and also accelerate research on phylogenetic evolution and analyze transgenetic silence of fungi.
作者 邱立友 余翠 戚元成 高玉千 申进文
机构地区 河南农业大学生命科学学院
出处 《细胞生物学杂志》 CSCD 2009年第2期212-216,共5页 Chinese Journal of Cell Biology
关键词 真菌 表观遗传 重复序列诱导的点突变 减数分裂前诱导的甲基化 DNA甲基化 fungi eigentics repeat-induced point mutation methylation induced premeiotically DNA methylation
分类号 Q93 [生物学—微生物学]
  • 相关文献

参考文献38

  • 1Selker EU, Cambareri EB, Jensen BC, et al. Rearrangement of duplicated DNA in specialized cells of Neurospora, Cell, 1987, 51(5): 741-752.
  • 2Kouzminova EA, Selker EU. dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora, EMBO J, 2001, 20(15): 4309-4323.
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  • 9Galagan JE, Selker EU. RIP: the evolutionary cost of genome defense, Trends Genet, 2004, 20(9): 417-423.
  • 10Watters MK, Randall TA, Margolin BS, et al. Action of repeatinduced point mutation on both strands of a duplex and on tandem duplications of various sizes in Neurospora, Genetics, 1999, 153(2): 705-714.

二级参考文献10

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同被引文献62

  • 1朱衡,瞿峰,朱立煌.利用氯化苄提取适于分子生物学分析的真菌 DNA[J].真菌学报,1994,13(1):34-40. 被引量：307
  • 2Selker E U, Cambareri E B, Jensen B C, et al. Rearrange- ment of duplicated DNA in specialized ceils of Neurospora [J]. Cell, 1987, 51(5):741 -752.
  • 3Galagan J E, Selker E U. RIP : the evolutionary cost of ge- nome defense [J]. Trends Genet, 2004, 20 (9) : 417 - 423.
  • 4Selker E U. Premeiotic instability of repeated sequences in Neurospora crassa [J]. Rev Genet, 1990, 24 ( 1 ) : 579 - 613.
  • 5Watters M K, Randall T A, Margolin B S, et al. Action of repeat -induced point mutation on both strands of a duplex and on tandem duplications of various sizes in Neurospora [J]. Genetics, 1999, 153(2):705 - 714.
  • 6Cambareri E B, Singer M J, Selker E U. Recurrence of re- peat- induced point mutation (RIP) in Neurospora crassa [J]. Genetics, 1991, 127(4):699 - 710.
  • 7Cambareri E B, Jensen B C, Schabtach E, et al. Repeat - induced G - C to A - T mutations in Neurospora [J]. Sci- ence, 1989, 244(4912) :1571 - 1575.
  • 8Irelan J T, Hagemann A T, Selker E U. High frequency re- peat- induced point mutation (RIP) is not associated with efficient recombination in Neurospora [J]. Genetics, 1994, 138(4) :1093 - 1103.
  • 9Borkovich K A, Alex L A, Yarden O, et al. Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to muhicellular organism [J]. Mol. Biol. Rev, 2004, 68(1) :1 - 108.
  • 10Crouch J A, Glasheen B M, Giunta M A, et al. The evolu- tion of transposon repeal - induced point mutation in the ge- nome of Colletotrichum cereale: reconciling sex, recombina- tion and homoplasy in an "asexual" pathogen [J]. Fungal Genet Biol. , 2008, 45(3) : 190 -206.

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细胞生物学杂志
2009年 第2期

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