摘要
目的建立一套完善的中医证候动物模型的评价方法。方法以2,4-二硝基苯酚诱导的热病证候模型为切入点,借助代谢组学平台,通过对空白对照组及模型组大鼠尿液的代谢指纹数据及模型组不同时间段尿液的代谢组进行分析,探讨动物模型的评价方法。结果通过代谢组学研究,结果表明2,4-二硝基苯酚诱导的动物模型符合中医临床的热病证候表征。结论代谢组学可用于中医证候动物模型的评价研究。
Aim To establish a set of consummate evaluation methods of animal models which are with syndromes of traditional Chinese medicine. Method By means of 2,4-dinitrophenol-induced fever syndrome model for the entry point, making use of meta bonomics as the platform, through analyzing metabolic fingerprint data of rat urine in the control and model group and metabolome of rat urine in model group at different time intervals, to approach the evaluation methods of animal models. Re-suits Through research by metabonomics, the results showed that 2, 4-dinitrophenol-induced animal models consisted with clinical fever syndrome of traditional Chinese medicine. Conclusion Metabonomics can be used for evaluation studies of animal models which are with syndromes of traditional Chinese medicine.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2009年第4期549-551,共3页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展计划(973计划)资助项目(No2007CB512608)
