摘要
[目的]探讨以冲击化疗为主后行放射治疗肺癌所致上腔静脉综合征的综合治疗临床效果。[方法]回顾分析31例肺癌致上腔静脉压迫综合征患者,先联合化疗;小细胞肺癌用CE（CBP;VP-16）或COME（CTX;VCR;MTX;VP-16）方案、非小细胞肺癌用CAP（CTX;ADM;PDD）或MVP（MMC;VDS;PDD）方案,配合消炎、利水、抗凝等综合治疗,症状体征缓解后开始放射治疗,总剂量DT4000～6000CGY,放疗结束3～4周再加强1个周期化疗。[结果]31例肺癌所致上腔静脉压迫综合征患者经上述治疗后完全缓解（CR）15/31（48.3%）,部分缓解（PR）10/31（32.2%）,无变化（NC）4/31（12.9%）,进展（PD）2/31（6.4%）,总有效率（CR＋PR）25/31（80.6%）。[结论]肺癌所致上腔静脉压迫综合征患者首先以冲击化疗为主的综合治疗措施,后行放疗对病情缓解,改善生活质量有利。
[ Objective] This study is an investigation of the combined treatment of superior vena cava syndrome （SVCS） from lung cancer patients. [ Methods ] Clinical data of 31 patients with SVCS from lung cancer admitted to the hospital were retrospectively analyzed. The patients had been undergone chemotherapy as follows： Patients with small cell lung cancer were treated with CE （ CBP ; VP - 16） or COME （ CTX ; VCR ; MTX ; VP - 16）, while those with Non - small cell lung cancer were treated with CAP（ CTX ; ADM ; PDD） or MVP（ MMC ; VDS ; PDD）, companied by anti - infection, anticoagulation and so on. When symptom had been relieved, radiotherapy was applied with dose arrange from 4000 to 6000 CGY. After the 3 to 4 week rest, one period of chemotherapy was used. [ Results] In whole group , complete response （CR） was achieved in 15 patients （48.3%）, partial response （PR） was found in 10 patients （32.2%）, no change （NC） was seen in 4 patients （ 12.9% ）, progressive disease （PD） was observed in 2 patients （6.4%） and the overall response rate （ CR ＋ PR） reached 80.6 %. [ Conclusion] The combined treatment with chemotherapy followed by radiotherapy is good for patients with SVCS from lung cancer.
出处
《大连医科大学学报》
CAS
2009年第2期198-199,203,共3页
Journal of Dalian Medical University
关键词
上腔静脉综合征
肺肿瘤
化疗
放疗
superior vena cana syndrome
lung carcinoma
radiotherapy
chemotherapy
