摘要
原发性睾丸淋巴瘤(PTL)是60岁以上男性常见的睾丸恶性肿瘤,常见的病理类型是弥漫大B细胞淋巴瘤。PTL有明显的结外侵犯趋势,常侵犯中枢神经系统、对侧睾丸、皮肤、韦氏环、肺、胸膜及软组织。PTL患者初始治疗应选择手术治疗。对于Ⅰ_E的PTL采用术后全身化疗、预防性鞘内注射及对侧睾丸的预防性照射,对于Ⅱ_E的患者加用区域淋巴结照射。Ⅲ～Ⅳ期的PTL术后以全身化疗为主,对于全身治疗达到完全缓解的再行对侧睾丸的预防性照射及预防性鞘注。PTL在复发方式及预后等方面与其他非霍奇金淋巴瘤有很大区别,应将其看作一种独特的临床疾病。
Primary testicular lymphoma （PTL） is a common testicular tumor in men after 60 years. PTL tends to involve extranodal sites including controlateral testis, CNS, skin, Waldeyer＇s ring, lung, pleura, and soft tissue. Orchidectomy is the initial treatment, followed by chemotherapy. Prophylactic irradiation of the contralateral testis is the recommended as the first - line treatment for patients with stage Ⅰ E - Ⅱ E diseases. In patients with stage Ⅱ E disease, irradiation of the involved lymph nodes is recommended. Standard therapeutic option for patients with stage Ⅲ - Ⅳ disease is chemotherapy. When patients achieve complete resgonse, prophylactic scrotal radiotherapy and intratheeal chemotherapy may be added.
出处
《癌症进展》
2009年第2期135-140,共6页
Oncology Progress
