摘要
目的:观察辨证施治对拉米夫定治疗慢性乙肝的增效作用及其对树突状细胞功能的影响。方法:收集120例慢性乙肝E-抗原阳性患者,分为观察组与对照组,观察组采用中医中药联合拉米夫定治疗,对照组仅用拉米夫定治疗,定期观察临床症状、肝功能、乙肝三系、HBV-DNA、YMDD变异等指标,疗程均为1年。疗程结束后两组各随机抽取30例病例,采集外周血检测树突状细胞表型及功能。结果:观察组与对照组相比,在改善临床症状、缩短肝功能、病毒载量恢复时间,提高E-抗原转换率、延长YMDD变异时间等方面经统计学处理有明显差异(P<0.05);观察组治疗后树突状细胞表型CD1 a、CD80、CD86、HLA-DR、ICAM-1明显高于对照组,经统计学处理有明显差异(P<0.05或P<0.01);刺激指数亦明显高于对照组(P<0.05)。结论:辨证施治能够提高拉米夫定治疗慢性乙肝的疗效,其机理与树突状细胞功能有关。
Objective： To observe the effect of synergy and the influence on dendritic cell function that determining the treatment based on differentiation of symptoms and signs to chronical hepatitis B treated by Lamivudine.Methods： 120 patients,with HBeAg positive were divided into two groups at random： observation group and control group,each group having sixty patients.Patients in the control group were only given to Lamivudine.Patients in the observation group were given to Lamivudine the usage same as control group and traditional Chinese medicine and drug.Observation item： Clinical symptoms、Liver function、HBV-DNA,HBeAg,YMDD.30 patients were selected each group that were detected dendritic cells phaenotype and function after treatment.Results： These of improving clinical symptoms,HBeAg divert,YMDD variation liver function and HBV-DNA＇s recovery were significantly different than those of control group.Dendritic cells phaenotype of observation group such as CD1a,CD80,CD86,HLA-DR,ICAM-1 were higher than those of control group（P〈0.05orP〈0.01）;stimulation index and excreted factor IL-12 of observation group were higher than those of control group（P〈0.05）.Conclusion： That determine the treatment based on differentiation of symptoms and signs can significantly improve the curative effect of chronical hepatitis B treated by Lamivudine and reduce the YMDD variation.one of the mechanism may be that it can improve dendritic cell function.
出处
《中华中医药学刊》
CAS
2008年第12期2752-2756,共5页
Chinese Archives of Traditional Chinese Medicine
关键词
辨证施治
拉米夫定
乙型肝炎
树突状细胞
Determine the treatment based on differentiation of symptoms and signs
lamivudine
hepatitis B virus
dendritic cells
