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泛素连接酶E3和肿瘤关系的研究进展 被引量：3

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摘要 决定蛋白质最后命运的是一类蛋白水解酶，在真核细胞中主要有两种蛋白质水解体系负责蛋白质的降解：溶酶体（lysome）和泛素一蛋白酶体（ubiquitinproteasome）。前者为人们所熟知，后者是近20年来科学家重点研究的目标。
作者 程翌 郑国荣
机构地区 广州军区武汉总医院消化内科
出处 《实用医学杂志》 CAS 北大核心 2009年第8期1341-1342,共2页 The Journal of Practical Medicine
关键词 泛素连接酶E3 肿瘤关系 蛋白质水解 蛋白水解酶 蛋白酶体 真核细胞 溶酶体 科学家
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

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  • 2Weissman A M. Themes and variations on ubiquitylation [J]. Nat Rev Mol Cell Biol, 2001, 2(3) : 169-178.
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同被引文献23

  • 1Penson DF, Rossignol M, Sartor AO, et al. Prostate cancer: epi- demiology and health-related quality of life[J]. Urology, 2008, 72 (6 Suppl) : S3-11.
  • 2Buschemeyer WC 3rd, Freedland SJ. Obesity and prostate cancer: epidemiology and clinical implications [J]. Eur Urol, 2007, 52 (2): 331-343.
  • 3Gater A, Abetz-Webh L, Battersby C, et al. Pain in castration- resistant prostate cancer with bone metastases: a qualitative study [J]. Health Qual Life Outcomes, 2011, 9: 88.
  • 4Azuma H, Inamoto T, Takahara K, et al. Combination therapy with VPI 6 and ethinylestradiol for hormone-refractory prostate can- cer: good response with tolerability[J]. Anticancer Res, 2010, 30 (9) : 3737-3745.
  • 5Cheville JC, Tindall D, Boelter C, et al. Metastatic prostate car- einoma to bone: clinical and pathologic features associated with cancer-specific survival[J]. Cancer, 2002, 95 (5): 1028-1036.
  • 6Chen C, Sun X, Guo P. Ubiquitin E3 ligase WWPI as till onco- genic factor in human prostate cancer [J). Oncogene, 2007, 26 (16) : 2386-2394.
  • 7Hideshima T, Richardson P, Chauhan D, et al. The proteasomeinhibitor PS-341 inhibits growth, induces apoptosis, and over- comes drug resistance in human multiple myeloma cells [J]. Cancer Res, 2001, 61: 3071-3076.
  • 8Ocean A J, SchnoU-Sussman F, Chert X, et al. Phase/i study of PS-341 (VELCADE, bortezomib) with or without irinoteean in patients (pts) with advanced gastric adenocarcinomas (AGA)[J]. 2005 Gastrointestinal Cancers Symposium, [Abstract 31 ] .
  • 9Zhu Y, Li T, Song J, et al. The TIR/BB-Ioop mimetic AS-I pre- vents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88- dependent signaling[J]. Basic Res Cardiol, 2011, 106 (5): 787- 799.
  • 10Alaaeddine N, De Montigny C, Sadouk M. Real-time reverse transcription-polymerase chain reaction quantification of tumor necrosis factor alpha messenger in human leukocytes [J]. Clin Lab, 2011, 57 (9): 799-802.

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实用医学杂志
2009年 第8期

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