摘要
目的探讨治疗结核性包裹性胸腔积液的最佳方式。方法将200例结核性包裹性胸腔积液患者随机分为两组,所有患者均采用2HRZE/6HR方案抗结核治疗,两组患者分别采用中性静脉导管胸腔置入加胸腔内注入尿激酶、胸穿加胸腔内注入尿激酶这两种方法引流胸腔积液,然后进行对比。结果治疗1个月时,两组的胸腔内分隔消失率分别为82.86%和58.95%;治疗2个月时,两组患者胸膜厚度与治疗前相比,均明显减少,差异有统计学意义;两组患者胸水消失时间比较有显著性差异;治疗6个月时两组的总有效率分别为81.90%和56.84%,两组对比有显著性差异。结论胸腔注入尿激酶可减少分房及分隔,减轻胸膜肥厚。胸腔置管+胸腔内注入尿激酶是治疗结核性包裹性积液的最佳方式,且安全、简便,值得在临床推广使用。
Objective To explore the best treatment of tuberculosis pleural effusion. Methods Two hundred loculated tuberculosis pleural effusion were randomly divided into two groups, all patients received the 2HRZE/6HR therapy,while the patients in one group received Intrapleural urokinase via the percutaneous transthoracic central venous catheter, the patients in another group were received Intrapleural urokinase after thoracentesis. Then comparison were made between two groups. Results By the end of one month treating, the disappearing rate of the fibrin band in two groups is 82.86% and 58.95% respectively, By the end of two months treating, the thickness of pleura in the two groups reduced significantly compared with the begin, there is significant difference between the two groups in the absorption time of pleural fluid. By the end of six months treating,the effective rate in the two groups was 81.90% and 56.84% ,there was significant difference between the two groups. Conclusions Intrapleural urokinase could reduce the fibrin band and the residual pleural thickening. Intrapleural urokinase via the percutaneous transthoracic central venous catheter is the best way for the loculated tuberculous pleural effusion, it is safe, effective and simple, so the clinical application should be approached extensively.
出处
《医学信息（内.外科版）》
2009年第2期114-116,共3页
Medical Information Operations Sciences Fascicule
关键词
结核
胸腔积液
尿激酶
胸腔注药
tuberculosis
pleural effusion
urokinase
intrapleural injection
