摘要
目的研究传染性单核细胞增多症(IM)患儿血清中的免疫球蛋白和外周血T淋巴细胞亚群变化及其临床意义。方法采用透射比浊法和APAAP法检测了36例生长发育正常的IM患儿血清Ig和T淋巴细胞亚群。结果IgG、IgA、CD4、CD4/CD8比值明显低于对照组(P<0.01),CD3、CD8明显高于对照组(P<0.01),IgM与对照组比较无显著性差异(P>0.05)。结论EB病毒感染后引起机体体液和细胞免疫功能异常是IM发病的关键,为临床IM患儿的免疫治疗提供了理论依据。
Objective ： To study on the changes of the immunoglobnin and T lymphocyte subtype in children with infectious mononucleosis （IM） and its clinical significance. Methods ： The transmittance turbidimetry and the APAAP assag were usted to determined the serum level of immunoglobulin （Ig） and T lymphocyte subtype in 36 cases of IM . Results ： The study showed that levels of IgG, IgA, CD,, as well as the ratio of CD4/CDs significantly reduced in comprison with normal controls （NC） （ P 〈 0. 01 ）, CD3, CDs cells were greatly increased （ P 〈 0. 01 ）, the serum level of IgM was no remarkable difference in comparison with NC （ P 〉 0.05 ）. Conclusion ： The abnormal function of humoral immunity and cellular immunity after EBV infection were the crux of the invasion of IM, its were indicated for adoptive immunotherapy.
出处
《中国优生与遗传杂志》
2009年第4期19-20,共2页
Chinese Journal of Birth Health & Heredity
