摘要
目的：观察内皮素受体拮抗剂对烧伤后肾功能损害的防治作用。方法：凝固汽油烧伤Ｗｉｓｔａｒ大鼠背部皮肤制成３０％ＴＢＳＡⅢ度烧伤模型，烧伤后５ｍｉｎ自股动脉分别输入生理盐水、选择性内皮素Ａ受体（ＥＴＡ）拮抗剂ＰＤ１４７９５３和非选择性内皮素受体（ＥＴＲ）拮抗剂ＰＤ１４５０６５。观察肾皮质血流和肾功能改变。结果：特异性阻断内皮素－１（ＥＴ－１）／内皮素－３（ＥＴ－３）作用可明显改善烧伤后肾缺血，减轻肾功能损害，以非选择性ＥＴＲ拮抗剂效果更好。结论：ＥＴ－１或ＥＴ－３升高及两种受体亚型的上调是烧伤后肾缺血肾功能受损的重要因素，外源性提供ＥＴＲ拮抗剂阻断ＥＴ－１／ＥＴ－３生物作用是防治烧伤后肾功能损害的又一新途径。
Objective: To observe the protective effects of endothelin receptor (ETR) antagonists on renal function after burns. Methods: After the Wistar rats were inflicted with 30% TBSA fullthickness skin burns, the selective endothelin A receptor antagonist PD147953 and nonselective ETR antagonist PD145065 were continuously infused into the abdominal aorta for 3 hours. Then the changes in renal cortical blood flow and renal function were observed. Results: After severe burns, ETR antagonists could markedly improve renal cortical blood flow and provide significant protection to renal function in rats. Conclusion: The increase of ET and upregulation of ETR play important roles in the pathogenesis of renal function impairment postburn. Infusion of exogenous ETR antagonists might be a new method for prevention and treatment of acute renal failure postburn.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1998年第2期93-95,共3页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
烧伤
内皮素受体
拮抗剂
肾功能损害
burn
endothelin receptor antagonist
renal impairment
rat
