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GluR2缺失的AMPARs在突触可塑性机制中的研究进展 被引量：4

Role of GluR2-lacking AMPAR in synaptic plasticity:recent progress
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摘要 α-氨基-3-羟基-5-甲基-4-异唑-丙酸(AMPARs)是调节快速突触传递的兴奋性谷氨酸受体,是由GluR1、GluR2、GluR3和GluR4四种亚基选择性组装构成同源或异源四聚物。GluR2亚基对AMPARs的特性有重要影响,含GluR2亚基的AMPARs对Ca2+不通透,中枢神经系统中大多数AMPARs为此类;不含GluR2亚基的AMPARs对Ca2+有较好的通透性,这类AMPARs在限定的神经元或特定的生理或病理条件下表达。近年来的研究发现,GluR2缺失的AMPARs对突触功能、突触可塑性、神经局部环路传导等有特殊的作用。本文对GluR2缺失的AMPARs及其对突触功能和可塑性的作用作一综述。 AMPARs are excitatory glutamate receptors that mediate the fast synaptic transmission. AMPARs are homo-or hetero-tetramers composed of selective combinations of four subunits： GluR1, GluR2, GluR3 and GluR4. AMPARs containing GluR2 are mainly in the central nervous system and are Ca^2＋ impermeable. MPARs-lacking GluR2 are Ca^2＋ permeable, and GluR2-qacking AMPARs are confined to certain neurons or certain physiological or pathological conditions. Recent research showed that GluR2 lacking AMPARs play special roles in the synaptic function and plasticity and transduction of local signal transduction. This paper reviews the GluR2-1acking AMPARs and their roles in the synaptic function and plasticity.
作者 魏显招 王雪琦
机构地区 第二军医大学长海临床医学院 第二军医大学长征医院肾内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2009年第4期437-441,共5页 Academic Journal of Second Military Medical University
基金 上海市重点学科建设项目(B902)~~
关键词 AMPA受体 GluR2亚基 突触可塑性 AMPA receptors GluR2 subunits synaptic plasticity
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献50

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同被引文献81

  • 1孟玮,廖素群,肖鹏,李东风.鸟类神经系统的长时程增强[J].心理科学进展,2005,13(3):333-340. 被引量：5
  • 2王晓东,肖鹏,李东风.鸣禽前脑X区结构功能的研究进展[J].Zoological Research,2005,26(3):332-336. 被引量：3
  • 3王铭杰,岳少杰.谷氨酸及其N-甲基-D-天冬氨酸受体在肺损伤中的作用[J].国际呼吸杂志,2007,27(21):1615-1618. 被引量：2
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  • 6Zhai D,Li S,Wang M,et al.Disruption of the GluR2/GAPDH complex protects against ischemia-induced neuronal damage[J].Neurobiol Dis,2013,54(6):392-403.
  • 7Mahajan SS,Thai KH,Chen K,et al.Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme,adenosine deaminase acting on RNA 2,and loss of GLUR2 editing[J].Neuroscience,2011,189(8):305-315.
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引证文献4

二级引证文献11

第二军医大学学报
2009年 第4期

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