摘要
目的探讨手汗症患者的遗传方式。方法采用分离分析法和Penrose法对23个手汗症高发家系进行分析。结果一、二级家属手汗症的患病率为9.80%(40/408),其中一级亲属为30.21%(29/96),二级亲属为3.53%(11/312)。手汗症的患病率高低与亲缘关系的近远呈显著相关。手汗症的遗传方式不符合常染色体显性遗传和性染色体连锁遗传,也不符合多基因遗传,而符合常染色体隐性遗传。结论手汗症高发家系的遗传方式为常染色体隐性遗传可能性大。
Objective To study the inheritance pattern of the primary palmar hyperhidrosis （PPH）. Methods Using segregation analysis and the Penrose＇s method, 23 families with high incidence of PPH were studied. Results The PPH incidence rate for the first and second degree relatives is 9.80 % （40/408）. The percentage of the first degree relatives with PPH is 30.21% （29/96） and it is 3.53% （11/312） for the second relatives. The incidence rate is significantly associated with the closeness to the consanguineous proband. The inheritance of familial PPH fits a typical autosomal recessive pattern, but not autosomal dominant and sex-linked inheritance, nor a polygenic inheritance pattern. Conclusion The inheritance pattern of familial PPH suggests an autosomal recessive mode of transmission.
出处
《福建医科大学学报》
2009年第2期156-158,共3页
Journal of Fujian Medical University
基金
福建省自然科学重点课题(2007Y0015)
关键词
汗脉疾病
交感神经系统
手
基因
隐性
连锁(遗传性)
染色体图
sweat gland diseases
sympathetic nervous system
hand
genes, recessive
linkage（genetics）
chromosome mapping
