摘要
目的探讨胆汁CEA、CA19-9联合检测对肝外胆管癌及壶腹癌诊断价值。方法观察组38例肝外胆管癌及壶腹癌患者在行ERCP检查前检测血清CEA及CA19-9,行ERCP检查时经造影导管抽取胆汁5ml用放免方法检测CEA及CA19-9,同时在导丝引导下自胆管咬取活检行病理检查,并记录影像学特征;同样,对照组30例非恶性病变患者在行ERCP检查时抽取5ml胆汁检测CEA及CA19-9。结果观察两组患者胆汁CA19-9、CEA水平明显高于对照组,有统计学意义(P<0.05),与病理结果一致;观察组患者胆汁及血清CA19-9水平比较,有统计学差异(P<0.05),而CEA水平无明显差异(P>0.05)。结论胆汁CEA、CA19-9联合检测对肝外胆管癌及壶腹癌的定性诊断有重要临床价值。
Objective To determine the valuable tumormarkers of CEA and CA19 -9 in the bile for diagnosis of cholangio- carcinoma and carcinoma of ampulla. Methods Serum CEA and CA19 -9 were detected by radio immunoassay in 38 patients of observation group with cholangiocarcinoma and carcinoma of ampulla before endoscopic retragrade cholangiopancreatography（ ERCP）, took 5ml bile to detecte CEA and CA 19 -9 While ERCP, and took endoscopic biopsy for histopatho- logical with the help of wise, recorded the feature of imaging. Bile CEA and CA19 - 9 were detected in 30 patients with unmalignant of contrast group in the same way. Results There were significance in the bile level of CEA or CA 19 - 9 be- tween the two groups （P 〈 0. 05 ） , it is coincide to the histopathological. There were significance in the level of CA 19 -9 between the bile and the serum （ P 〈 0. 05 ）, but no significance in the level of CEA （ P 〉 O. 05 ）. Conclusion The tumor- markers of CEA and CA19 -9 in the bile for diagnosis of cholangiocarcinoma and carcinoma of ampulla have important val- uable.
出处
《临床肝胆病杂志》
CAS
2009年第2期125-126,共2页
Journal of Clinical Hepatology
