摘要
用放射免疫法测定３１例急性脑梗塞患者和１６例高血压患者血浆及体外诱生的单核细胞源性及地塞米松（ＤＸＭ）干预后的内皮素（ＥＴ）水平。结果发现：急性脑梗塞组体外诱生的单核细胞源性ＥＴ水平明显增高，并与血浆中ＥＴ水平及神经损伤程度正相关；ＤＸＭ干预后，体外诱生的单核细胞源性ＥＴ水平降低。提示：急性脑梗塞时，单核细胞增加ＥＴ的合成与释放可能是其参与缺血性脑损伤过程的机制之一，而ＤＸＭ则抑制其合成与释放。
To investigate the mechanism that monocytes participate in ischemic brain injury, endothelin (ET) levels in plasma, supernatants of cultured monocytes in vitro and those pretreated by dexamethason(DXM) were assayed by radioimmunoassay in 31 patients with acute cerebral infarction and 16 patients with hypertension (served as control). Compared with the control group, the ET levels in supernatants of cultured monocytes increased and positively related with those in plasma and degree of neurological damage in the acute cerebral infarction group; while the ET levels in supernatants of cultured monocytes pretreated by DXM decreased. This suggests that intensifying the synthesis and release of ET may be one of the mechanisms for the involvement of monocytes in the pathologic process of ischemic brain injury during acute cerebral infarction. DXM can improve this process by inhibition of producing monocyte-derived ET.
出处
《湖南医科大学学报》
CSCD
1998年第2期184-186,共3页
Bulletin of Hunan Medical University
