摘要
采用膜迷路铺片、火棉胶切片、透射电镜及内耳电生理检测技术，观察正常豚鼠透明质酸－链霉素（ＨＡ－ＳＭ）圆窗灌注后内耳功能和形态学变化，为临床应用提供实验依据。灌注后眼震时间明显缩短（Ｐ＜０．０１），而耳蜗电图无明显变化（Ｐ＞０．０５）；形态学观察示前庭感觉细胞严重破坏，而Ｃｏｒｔｉ器无明显损害。结果表明：ＨＡ－ＳＭ圆窗灌注可选择性破坏前庭功能。
To investigate the effects of the hyaluronic acidstreptomycin(HASM) perfusion through round window on the function and morphology of the inner ear in guinea pig, membrous labyrinth mapping, temporal bone section after celloidin embedding, transmission electron microscopy, electrocochlegraphy (ECochG) and electronystagmography (ENG) were examined. The nystagmus duration induced by caloric test was obviously reduced in comparison with that of the preoperation (P<0.01), while the action potential (AP) by ECochG was not obviously changed. The sensory cells of estibular organs were severely damaged, while the morphology of corti's organs were not significantly damaged after HASM perfusion. The results suggest that the HASM perfusion through the round window may selectively destroy the vestibular function, whereas the auditory function is not obviously damaged.
出处
《湖南医科大学学报》
CSCD
1998年第2期133-136,共4页
Bulletin of Hunan Medical University
关键词
透明质酸
链霉素
圆窗灌注
迷路
豚鼠
内耳
hyaluronic acid
streptomycin
drug effect
therapy
round window
labyrinth
morphology
evoked potential auditory
vestibular function tests
guinea pig
