摘要
目的:探讨纳甲法针刺对类风湿性关节炎大鼠的治疗作用和机理。方法:以完全弗氏佐剂关节局部注射造成大鼠类风湿关节炎模型(AA),随机分为正常对照组、模型组、纳甲法针刺组,分别处理后测定各组血清皮质醇、大鼠关节肿以及病理改变。经统计学处理,比较组间差异。结果:模型组大鼠血清皮质醇含量较正常组显著降低(P<0.05),治疗后纳甲法针刺组血清皮质醇升高,同模型组比较差异显著(P<0.05),而与正常组对比无差异(P>0.05)。治疗后纳甲法针刺组大鼠关节肿胀度和病理改变亦较模型组显著降低(P<0.05)。结论:纳甲法针刺对其关节肿胀情况和病理方面有明显改善且可能与调节血清皮质醇含量有关,其针刺的作用机理可能与生物节律等时间因素有关。
Objective ： To approach to the effect and mechanism of Day - prescription acupuncture for treatment of rheumatoid arthritis（RA）. Methods：Adjuvant arthritis （AA） rats were used as RA rat model and they were randomly divided into normal Control group, Model group, Day - prescription Acupuncture group. After treatment serum Cortisol Contents were determined. The swell of joint and greatness were observed. After statistics processing, compared with group difference. Resuhs：The serum Cortisol Content in the model group was lower than the normal group （P 〈 0. 05）. After treatment the serum Cortisol Content Day - prescription Acupuncture group was higher than the model group （ P 〈 0.05 ）. Cortisol were no significent difference between Day -prescription Acupuncture group and the normal group（ P 〉 0.05 ）. After treatment the joint＇s swell and greatness of other teams was lower than the model group （P 〈 0. 05 ）. Conclusion.The variation of The joint＇s swell and greatness serum is related to serum Cortisol Contents. The mechanism of Day - prescription Acupuncture is probably related to the time.
出处
《中华中医药学刊》
CAS
2009年第1期170-172,共3页
Chinese Archives of Traditional Chinese Medicine
基金
滨州医学院科研启动基金项目(BY2005KYQD05)
