摘要
谷胱甘肽是一个由谷氨酸、半胱氨酸及甘氨酸组成的三肽,具有抗氧化和解毒等功能。近年来研究发现谷胱甘肽的胆汁外排是生成非胆汁酸依赖型胆汁流的重要驱动力,谷胱甘肽的胆汁外排受阻可引起胆汁淤积。本文对谷胱甘肽的肝脏转运通路及其在胆汁淤积中的作用的研究进展进行综述。基于谷胱甘肽对胆汁流的驱动作用,增强谷胱甘肽的胆汁外排转运可望成为胆汁淤积防治的新靶点。
Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第4期327-332,共6页
Acta Pharmaceutica Sinica
关键词
谷胱甘肽
肝脏转运
多药耐药相关蛋白
胆汁淤积
glutathione
hepatobiliary transport
multidrug resistance associated protein
cholestasis
