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低分子肝素抑制肿瘤转移的研究进展 被引量：2

Role of low-molecule-weight heparin in cancer metastasis
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摘要 肿瘤转移是一个复杂的过程，而针对转移治疗一直是研究的热点。低分子肝素通过抑制肝素酶对基底膜的降解、降低血液黏稠度等作用，对肿瘤细胞转移有明显的干预作用。本文就低分子肝素（LMWH）对肿瘤转移过程影响和作用机制做一综述，讨论其抗肿瘤转移的临床应用价值。 Cancer metastasis is multi-step process that requires cancer cells to jump through many hoops. The low-molecule-weight heparin （LMWH） has been reported effective for the treatment of metastasis to some extent, the mechanisms are proposed as anticoagulation, inhibition of heparanase, selectins, adhesion, angiogenesis mediated by the tumor cells, and the effects on cell cycle and apoptosis.
作者 林义佳 徐建波 张常华
机构地区 中山大学附属第一医院胃肠胰外科
出处 《国际外科学杂志》 2009年第4期253-255,共3页 International Journal of Surgery
基金 国家自然科学基金项目（No.30700805） 广东省自然科学基金（No.07300940） 中山大学学生业余科研项目（No.800001163190）
关键词 低分子肝素 肿瘤转移 肝素酶 选择素 血管生成 low-molecule-weight heparin cancer metastasis heparinase selectin angiogenesis
分类号 R730.5 [医药卫生—肿瘤]
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参考文献20

  • 1Koliopanos A, Friess H, Kleeff J, et al. Heparanase expression in primary and metastatic pancreatic cancer [ J ]. Cancer Res, 2001, 61 (12) :4655-4659.
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同被引文献20

  • 1MARCHETYI M, VIGNOLI A, RUSSO L, et al. Endothelial capillary tube formafon and cell proliferation induced by tumorcells are affected by low molecular weight heparins and unfractionated heparin [ J ]. Thromb Res, 2008, 121 ( 5 ) : 637 - 645.
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  • 3NITORI N, INO Y, NAKANISHI Y, et al. Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma [ J ]. Clin Cancer Res,2005,11 (7) :2531 -2539.
  • 4GUAN M, JIN J. Tissue factor expression and angiogenesis in human glioma[ J]. Clin Biochem ,2002,35 (4) :321 - 325.
  • 5GONZALEZ-GRONOW M, GAWDI G, PIZZO SV, et al. Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells [ J ]. Blood, 2002,99 ( 12 ) :4562 - 4567.
  • 6UENO T,TOI M, KOIKE M, et al. Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration [ J . Br J Cancer,2000,83 (2) : 164 - 166.
  • 7POON RT, LAU CP, HO JW, et al. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma [ J ]. Clin Cancer Res, 2003,9 ( 14 ) : 5339 - 5345.
  • 8MOUSA SA, MOHAMED S. Anti-angiogenic mechanisms and efficacy of the low molecular weight heparin, tinzaparin: anti- cancer efficacy [ J ]. Oncol Rev ,2004 ,12 ( 4 ) : 683 - 688.
  • 9刘飞,李汉军,李介秋,汤恢焕,刘庚勋,葛健君,孔屏.低分子肝素对种植性乳腺癌生长和转移的抑制作用[J].中华实验外科杂志,2010,27(1):50-52. 被引量：3
  • 10蔡欣,程艳,王阿曼,刘基巍.恶性肿瘤并发血栓栓塞61例临床分析[J].临床肿瘤学杂志,2011,16(4):349-352. 被引量：21

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国际外科学杂志
2009年 第4期

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