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替诺昔康中间体的合成

Synthesis of the Intermediates of Tenoxicam
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摘要 以3-氯磺酰基-2-甲氧羰基噻吩为原料,用甘氨酸甲酯盐酸盐代替肌氨酸甲酯盐酸盐,经缩合、闭环、与硫酸二甲酯进行N-甲基化反应合成了替诺昔康的中间体4-羟基-2-甲基-2H-噻吩并[2,3-e]-1,2-噻嗪-3-甲酸甲酯-1,1-二氧化物。通过1HNMR确认了产物的结构。 The intermediate of tenoxicam, 4-hydroxy-2-methy1-2H-thieno [2,3-e]-1,2-thiazine-3- carboxylate-1,1-dioxide, was synthesized from 3 - （chlorosulfonyl） - 2 - thiophenecarboxylate and glyeine methyl ester hydrochloride instead of sareosine methyl ester hydroehloride by condensation, cyclization and N - methylation with dimethyl sulfate. The structures of the products were confirmed by ^1H NMR.
作者 江孝龙
机构地区 中国石化集团四川维尼纶厂
出处 《山东化工》 CAS 2009年第3期23-26,共4页 Shandong Chemical Industry
关键词 替诺昔康 中间体 缩合 合成 tenoxicam intermediate condensation synthesis
分类号 TQ252.5 [化学工程—有机化工]
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参考文献11

  • 1Todd P A , Clissold S P . Tenoxicam , An update of its pharmacology and therapeutic efficacy in rheumatic diseases[J]. Drugs, 1991 ,41 (4) : 625 -646.
  • 2Gonzales J P, Todd P A. Tenoxicam, A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs, 1987 , 3 4 ( 3 ) : 2 8 9 - 310.
  • 3Binder D , Hromatka O , Geissler F , et al. Analogues and derivatives oftenoxicam. 1. synthesis and antiinflammatory activity of analogues with different residues on the ring nitrogenand the amide nitrogen [ J ]. J Med Chem, 1987,30 (4) :678 - 682.
  • 4Corral C , Lissavetzky J , Alvarezinsua A S , et al . Synthesis of 3 - mercaptothiophene - 2 - and4 - carboxylic Acids[J]. Org Prep Proced Int ,1985 ,17 (3) :163.
  • 5Huddleston P R , Barker J M . A convenient synthesis of 2 - substituted3 - hydroxyand3 - amino - thiophensfrom derivatives of 2 - chloroacrylic acid [ J ] . Synth Commun , 1979,9 (8) :731 -734.
  • 6Pfister R , Zelter P , Binder D , et al . Thiazine derivatives : US, 4180662 [ P ]. 1979 - 12 - 25.
  • 7Pfister R , Zeller P , Binder D , et al . Thiazine derivatives : US, 1519811 [ P]. 1978 - 08 - 02.
  • 8Hromata O, Binder D, Pfister R. Thiazine derivatives : GB, 1519811[P]. 1978 -08 -02.
  • 9谢剑华,胡永洲.非甾体抗炎药替诺昔康的合成[J].中国药学杂志,2003,38(11):879-881. 被引量：4
  • 10Binder D. Thienithiazine derivatives: US, 5679678[ P]. 1997 - 10 - 21.

二级参考文献15

  • 1刘长令.2－甲氧羰基－3－噻吩磺酰氯合成方法述评[J].浙江化工,1995,26(4):6-9. 被引量：2
  • 2[1]Todd PA, Clissold SP. Tenoxicam, An update of its pharmacology and therapeutic efficacy in rheumatic diseases[J ]. Drugs, 1991,41(4) :625.
  • 3[2]Gonzalez JP, Todd PA. Tenoxicam, A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy[J]. Drugs, 1987,34(3) :289.
  • 4[3]Binder D, Hromatka O, Geissler F, et al. Analogues and derivatives of tenoxicam. 1. synthesis and antiinflammatory activity of analogues with different residues on the ring nitrogen and the amide nitrogen[J]. J Med Chem, 1987,30:678.
  • 5[4]Corral C, Lissavetzky J, Alvarez-insua AS, et al. Synthesis of 3-mercaptothiophene-2-and 4-carboxylic Acids [ J ]. Org Prep Proced Int, 1985,17(3): 163.
  • 6[5]Huddleston PR, Barker JM. A convenient synthesis of 2-substituted 3-hydroxy and 3-amino-thiophens from derivatives of 2-chloroacrylic acid[J]. Synth Commun, 1979,9(8):731.
  • 7[6]Mister R,Zeller P, Binder D, et al. Thiazine derivatives[P]. US.Patent,4180662. 1979-12-25.
  • 8[7]Pfister R, Zeller P,Binder D, et al. Thiazine derivatives[P]. United Kingdom Patent Specification, 1519811. 1978-08-02.
  • 9[1]Binder D, et al. Thienithiazine derivatives [ P]. US 5679678,1997-10-21
  • 10[3]Hromata O, Binder D, Pfister R. Thiazine derivatives [ P]. GB 1519811,1978-08-02

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山东化工
2009年 第3期

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