摘要
目的试图探索一种有效的治疗脑膜癌病的方法。方法对经CSF细胞学证实的ZO例脑膜癌病患者，经CSF双头蓄液囊装置行脑室内单-MTX化疗。结果治疗6周后，全部20例病人60％症状改善，25％稳定，45％病人症状稳定或好转1个月以上。存活期4－20周，平均12周。与脑室内化疗相关的副作用多数轻而短暂，严重并发症为5％。结论我们认为脑室内单一药物化疗能有效地改善病人的症状，延长存活期，值得进一步研究。
Objective To investigate a effective method in treatment of meningeal carcinomato-sis (MC). Method: Twenty patients with MC proved by CSF cytology were uniformly treated withintraventricular chemotherapy of methotrexate sodium via double-headed CSF reservoir. Results: 17patients showed a neurologic improvement or stabilization and 3 patients showed a worsening of theneurologic signs and had already died. Approximately half of the patients experienced improvementor stabilization of neurological symptoms for more than a month. Median survival was 12 weeks aftertreatment. Side effects of therapy were, for most part, transient and reversible, only one patient wasfatal (5%). Conclusion: It was suggested that treatment of MC with intraventricular singlechemotherapeutic agent improves symptomatology in some patients, and at times prolongs survivallive and quality of life, deserves further study.
出处
《中国肿瘤临床与康复》
1998年第5期9-11,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
山东省科委资助
关键词
脑膜癌病
脑室内化疗
蓄液囊装置
氯甲碟呤
Meningeal carcinomatosis Intraventricular chemotherapy Methotrexate sodium CSF reservoir device
