摘要
目的探讨不同品种柴胡枳实对胃肠动力的作用，选出作用较优者应用于临床．方法选南柴胡与北柴胡，酸橙枳实与甜橙枳实，以大分子色素葡聚糖蓝（BD）20O0为胃肠道标记物，以胃内色素残留率及小肠推进比为指标，比较4味药对小鼠胃肠推进功能的作用，并对由作用较明显的柴胡枳实制成的不同合剂及合剂的不同剂量，进行比较，筛选出作用较优的合剂及该合剂的最佳剂量结果北柴胡与酸橙枳实的胃内色素残留率及小肠推进比与阴性对照组相比有显著差异.而南柴胡与甜橙枳实与阴性对照组相比，差异无意义（P＞0．05）北柴胡与酸橙枳实的合煎剂促胃肠动力的作用优于单味药，亦优于分煎后混合，合煎剂的3倍常用量作用优于常用量．结论北柴胡、酸橙枳实及二者合煎剂的3倍常用量有较强的促胃肠动力的作用．
AIM To investigate the efferts of different varieties of Bupleurum and Citrus on gastrointestinal motility, in order to choose the better variety to use in clinic.METHODS Choosing the two main varieties of Bupleurum and Citrus, B. Chinese DC. (B. the), B.Scorzonerifolium Willd (B. sW) and Citrus aurantium (Ca), Citrus sinensis (Cs), as the test drugs, we compared the effects of 4 drugs, different mixtures of Bupleurum and Citrus and different dosage of the mixtures on mice gestrointestinal motility with Blue Dxtran 2000 as a marker in the gastrointestinal tract.RESULTS B. cDC. and Ca had obvious enhancing eftects on the gastric emptying function and small intestinal propulsive function, while the effect of B. sW and Cs had no difference with negative control group (P > 0.05 ). The effects of the mixture of B. cDC and Ca decoted together on the pestrointestinal motility proved to be more significant than single drug and the mixture of the above two herbs decoted respectively. 3 times usual dosage of the better mixture had a stronger enhancing effect on gastrointestinal motility than usual dosage.CONCLUSION B. cDC., Ca and 3-fold usual dosage of the mixture of above herbs decoted together has a stronger enhancing effect on gastrointestinal motility.
出处
《世界华人消化杂志》
CAS
1998年第S2期205-207,共3页
World Chinese Journal of Digestology
关键词
胃肠运动/药物作用
胃/药物作用
小肠/药物作用
柴胡/药理学
枳实/药理学
gastrointestinal motility/drug effects
stomach/drug effects
small intestins/drug effects
Bupleurum/pharmacology
Citrus/pharmacology
