摘要
目的探讨奥美拉唑、羟氨苄青霉素和小剂量呋喃唑酮混悬液对幽门螺杆菌（Hp）的根除率方法Hp相关的十二指肠溃疡和慢性胃炎患者136例，随机分为3组．第1组（n＝46）用奥美拉唑、羟氨等青霉素和小剂量呋喃唑酮混悬液三联治疗1wk．第2组（n＝45）用同样的药物和剂量2wk．第3组（n＝45）用胶体铋剂、羟氨苄青霉素和灭滴灵三联治疗2wk．Hp检测根据尿素酶试验和组织Warthin-Starry银染色法检查结果第1，2和3组的Hp根除率分别为88．9％，955％和71．4％．第1组与第3组，第2组与第3组比较差异均有显著性（P＜0．05），而第1组与第2组比较无明显差异．第3组患者出现不良反应者比前两组明显增多．结论奥美拉唑、羟氨苄青霉素和小剂量呋喃唑酮混悬液联合治疗Hp感染，具有根除率高和副作用少的优点．
AIM To study the eradication rate of Helicobacter pylori (Hp) infection using triple therapy of Omeprazole (Losec)amoxicillin and low-dose of furazolidone suspension.METHODS Hp associated chronic gastritis or duodenal ulcer patients (n=136) were randomly divided into 3 groups. Group 1 (n=46) and Ⅱ (n = 45) were treated with triple therapy of losec, amoxicillin and low-dose furazolidone suspension for 1 week, and 2 weeks. Group Ⅲ(n=45) were treated with triple therapy of colloidal bismuth subcitrate amoxicillin and metronidazole for 2 weeks. The Hp status was determied by rapid urease test and histology of Warthin-Starry silver stain.RESULTS The Hp eradication rates of Group Ⅰ,Ⅱ,and Ⅲ were 88.9%, 95.5% and 71.4% resPeCtively. The difference of eradication rate between Group Ⅰ and Group Ⅲ, or Group Ⅱ and Group Ⅲ was significant (P<0.05).the difference betWeen Group Ⅰ and Groop Ⅱ was statistically insignificant.The frequency of side effects in Group Ⅲ was higher than that in Group Ⅰ or Ⅱ.CONCLUSION The triple therapy with losec, amoxicillin and low-dose of furazolidone suspesion is an effective and Well tolerated treatment for eradication of Hp infection.
出处
《世界华人消化杂志》
CAS
1998年第S2期127-128,共2页
World Chinese Journal of Digestology
