摘要
目的：探讨烧伤延迟复苏脏器组织一氧化氮（ＮＯ）的变化与延迟复苏后多器官功能障碍发生的关系。方法：选用ＳＤ大鼠制备烧伤和烧伤休克延迟复苏模型，定时取心、肝、肾组织测定ＮＯ稳定代谢产物［ＮＯ２－＋ＮＯ３－］的水平及含水量。结果：烧伤后各器官组织中ＮＯ产生明显增加，而延迟复苏组各器官ＮＯ产生均较烧伤组显著地降低，组织含水量较烧伤组明显增高。结论：烧伤休克延迟复苏存在广泛的内脏组织再灌注损伤。
Objective: To test the production of NO in the heart, liver and kidney of rats sustaining delayed resuscitation of severe burn and investigate the mechanism of the viscera injuries after ischemia reperfusion. Methods: Using the Griess method, we measured the stable metabolites of NO in tissue of viscera. Results: Production of NO increased significantly after burn, but decreased significantly in delayed resuscitation group as compared with the burn group. Conclusion: Disturbance of NO production appears in burn and delayed resuscitation group. Decreasing of NO production may play a pivotal role in the injury of viscera after delayed resuscitation.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1998年第S1期112-113,共2页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
国家自然科学基金委员会杰出人才基金
上海市卫生系统百名跨世纪优秀学科带头人培养计划资助
关键词
一氧化氮
烧伤
延迟复苏
nitric oxide
burns
delayed resuscitation
