摘要
本文报道1例AML-M2a患者在造血干细胞移植中服用环孢素A(CsA)诱发急性胰腺炎并进行临床分析。1例49岁急性髓性白血病(AML-M2a)患者,在进行同胞HLA相合造血干细胞移植术后20天并发急性胰腺炎。预处理方案采用改良Bu/Cy方案,移植物抗宿主病(GVHD)预防包括环孢菌素A(CsA)、短程甲氨蝶呤(MTX)及抗胸腺细胞球蛋白(ATG)。结果表明:尽管患者腹部CT及彩超检查均显示胰腺无异常,但临床及实验室检查均支持急性胰腺炎的诊断。经过全身支持治疗及CsA减量患者最终得以缓解。结论:CsA是导致急性胰腺炎的可能诱因。
Pancreatitis has not been reported in allogeneic stem cell transplant（allo-SCT） recipients with cyclosporine in China. This article presented a case of acute pancreatitis in a 49-year-old patient with AML-M2a who received allogeneic stem cell transplant from her HLA identical sister. The preparative regimen consisted of busulfan and cyclophosphamide. The cyclosporine A, short-term methotrexate and antilymphocyte globufin （ATG）, were used to prevent the graft-versus-host disease （GVHD）. Clinical and laboratory signs of acute pancreatitis were found in the patient on day 20 post-transplant. A diagnosis of acute pancreatitis was made although the pancreas was apparently normal at abdominal contrast-enhanced tomography and ultrasonography. She recovered with supportive care and reduction of cyclosporine dose. In conclusion, cyclosporine is the probable cause of pancreatitis in this patient.
出处
《中国实验血液学杂志》
CAS
CSCD
2009年第2期472-475,共4页
Journal of Experimental Hematology
基金
广东省自然科学基金资助项目(No.06020896)
国家自然科学基金资助项目(No.30571771)
