摘要Trolline, a new bioactive alkaloid was isolated in 2004. We reported herein the first total synthesis of (±)-trolline, in two steps and 18.0% overall yield.
3WANG RF, YANG XW, MA CM, et al. A bioactive alkaloid from the flowers of Trollius chinensis[ J ]. Heterocycles, 2004, 63 (6) : 1443 - 1448.
4KAWAI N, MATSUDA M, UENISHI JI. Stereoseleetive synthesis of tetrahydroisoquinoline alkaloids: ( - )-trolline, ( + )-crispin A, ( +)-oleraeein E[J]. Tetrahedron, 2011, 67(45): 8648- 8653.
5SELVAKUMAR J, RAO RS, SRIN1VASAPRIYAN V, et al. Syn- thesis of condensed tetrahydroisoquinoline class of alkaloids by em- ploying TfOH-mediated imide carbonyl activation [ J ]. Ear J Org Chem, 2015,2015(10) : 2175 -2188.
6LAURA M, JAVIER P, ABRAHAM G, et al. Synthesis of new antimierobial pyrrolo [ 2,1 -a I isoquinolin-3-ones [ J ]. Bioorg Med Chem, 2012, 20(22): 6589-6597.
