摘要
目的评价奎硫平与氯氮平对首发精神分裂症患者的临床疗效和生活质量的影响。方法将病程≤3年的83例首发精神分裂症患者随机分为奎硫平组(42例)和氯氮平组(41例),分别给予奎硫平和氯氮平治疗8周,采用阳性与阴性症状量表(PANSS)评定疗效,副反应量表(TESS)评定不良反应,生活质量综合评定问卷(GQOLI-74)评定生活质量。结果奎硫平组与氯氮平组治疗8周后,两组疗效差异无显著性意义(P<0.05);奎硫平对躯体功能、心理功能的损害小于氯氮平,对社会功能的提高优于氯氮平。结论奎硫平比氯氮平能更好改善首发精神分裂症患者的生活质量。
Objective To evaluate the quetiapine and clozapine for schizophrenia clinical effect and quality of life. Methods The first 83 patients hospitalized schizophrenic patients were randomly divided into quetiapine group (42 ca- ses) and clozapine group (41 cases),respectively clozapine in the treatment of mild sulfur eight weeks.Positive and nega- tive symptom scale (PANSS)to evaluate the effect,deputy Scale (TESS)for adverse reactions,comprehensive assessment of the quality of life questionnaire(GQOLI-74)for the quality of life.Results Group quetiapine and clozapine group after 8 weeks there were no significant differences(P>0.05).Quetiapine group of physical function,psychological function of the damage is less than clozapine group to improve the functions of the community better than clozapine.Conclusion quetiapine clozapine better than first-episode schizophrenia patients improve the quality of life.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第S1期208-209,共2页
Chinese Journal of Practical Internal Medicine
关键词
首发精神分裂症
奎硫平
氯氮平
生活质量
First-episode schizophrenia
Quetiapine
Clozapine
Quality of life
