摘要
目的探讨脑缺血预适应(BIP)对急性脑梗死(ACI)的神经保护作用。方法收集2005年10月至2007年4月潮州市中心医院门诊及住院收治短暂性脑缺血发作(TIA)后发生 ACI 患者60例,其中30例 TIA 时长≤20 min 为 A1组,30例 TIA 时长>20 min且≤60 min 为 A2组;同期随机抽取 ACI 前无 TIA 的病例30例为 B组(对照组)。ACI 病例观察梗死病灶大小、神经功能评分、病变程度及疗效等指标。结果 TIA 后 ACI,A1组梗死病灶较小,神经功能评分较低,重度病例少,基本痊愈率、显效率及总有效率较高,优于对照组(P<0.01),而A2组差别则无显著性(P>0.05)。结论持续适当的 BIP 对其后发生的 ACI 能产生神经保护作用。
Ob- Jective To discuss whether Brain Ischemic Precondition(BIP) can provide neuroprotective effect to Acute Cerebral In- farction(ACI).Methods The transient ischemic attack(TIA)patients,who had ACI later from 2005-10 to 2007-04, were included into Group A(Observing Group).According to the TIA lasting time they were divided to 2 Groups.Group Alincluded 30 patients with T[A time≤20 minutes:Group A2 included 30 patients with TIA time>20 minutes and ≤ 60 minutes.Other 30 random ACI patients without TIA were included into Group B(Control Group).Several aspects were observed for comparing such as focus of infarction,neural function evaluation,pathological level and therapeutic effect.Re- sults ACI cases following T[A,Group AI patients' focuses of infarction were smaller and neural function evaluations were lower.There were also less serious patients.Group Al's Basic recovery rate,effective rate and total effective rate were higher than Control Group(P<0.01).But Group A2 had no significant difference with Control Group (P>0.05).Con- clusion The proper lasting BIP(ATI) can provide neuroprotective effect to the ACI following.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第S1期180-181,共2页
Chinese Journal of Practical Internal Medicine
关键词
脑缺血预适应
短暂性脑缺血发作
急性脑梗死
Brain ischemic precon-ditioning
Transient ischemic attack
Acute cerebral infarction
