摘要
目的比较NP方案时辰化疗与常规化疗治疗晚期乳腺癌的疗效及毒副作用。方法将52例晚期乳腺癌患者随机分为2组,2组均采用NP方案。时辰化疗组长春瑞滨(NVB)25mg/m^2静脉注射,17:00,第1、8天,顺铂(DDP)30 mg/m^2持续静脉滴注,10:00～16:00,第1～3天。而常规化疗组NVB与DDP均于10:00用药。结果时辰化疗组总有效率为69.2%;常规化疗组总有效率为30.8%,两组疗效比较差异有统计学意义(P<0.01)。主要毒副反应为血液学毒性及胃肠道反应,时辰化疗组均低于常规化疗组。结论NP方案时辰化疗疗效优于常规化疗,且毒副作用小。
Objective To compare the response and adverse reactions of NP time-chemotherapy with that of routine NP for advanced breast cancer.Methods 52 patients with advanced breast cancer were ran- domly assigned to groupA which received NP time-chemotherapy,or group B which received routine NP.Re- suits The overall response rate is 69.2 % in Group A compare to 30.8 % in group B,there was significant difference(P<0.01).The main adverse reactions include marrow suppression and gastrointestinal reactions, which is lower in Group A than in group B.Conclusion Compared to routine NP,NP Time-chemotherapy is an active and safe regimen for advanced breast cancer.
出处
《肿瘤研究与临床》
CAS
2007年第4期252-253,共2页
Cancer Research and Clinic
关键词
乳腺肿瘤
抗肿瘤联合化疗方案
时辰化疗
Breast neoplasms
Antineoplastic combined chemotherapy protocols
Timechemotherapy
