摘要
用ＧＣＭＳ联用技术对海南粗榧新碱衍生物ＨＨ０７Ａ在大鼠体内代谢转化进行了研究。尿样经ＸＡＤ２固相提取、酶水解、浓缩并硅烷化，用ＧＣＭＳ联用仪分离鉴定尿中ＨＨ０７Ａ及其４个代谢物，推断４个代谢物结构及其体内代谢途经。
The metabolism of HH07A in the rat has been investigated by GCMS. After oral administration of HH07A, the rat urine was passed through a macroporous XAD2 resin column and eluted with methanol. The methanol extract was hydrolyzed with glucuronidase, extracted with dichloromethane and concentrated for TMS derivatization with GCMS. The mass spectra of HH07A and its four metabolites as well as their derivatives were presented. The structures of the metabolites were proposed and the in vivo metabolic pathway of HH07A was given in Figure 6.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第3期212-216,共5页
Acta Pharmaceutica Sinica
