摘要
以Wistar大鼠为供体，SD大鼠为受体，在立体定向仪上将同种异体的甲状旁腺移植到SD大鼠的侧脑室。应用免疫细胞化学方法对移植后脑内c-fos的表达进行了研究。移植后24h，前脑内开始出现c-fos的表达，4d达到高峰，持续1周后逐渐减少。到移植后4周，c-fos表达基本消失。c-fos表达的部位主要出现在白质内（如胼胝体。前连合等）以及侧脑室周围的脑组织（如隔区、纹状体等）。诱导表达的c-fos阳性细胞呈簇状、大小不等，类似正在分裂增殖中的小胶质细胞和星形胶质细胞。本文结果提示，在同种异体甲状旁腺脑室内移植过程中c-fos的表达可能与胶质细胞的活化和增殖有关。
Wistar rats and SD rats were used as donors and recepients respectively. the paratbyroid gland (PTG) allografted into SD cerebroventricle. The c-fos onset eXPression was detected in the forebrain 24 hours after PTG allografting. The expression increased markedly from 1 to 4 days afte operation. From 7 days, the expression began declined and it disappeared by 4 weeks after operation. The distribution of c-fos expression cells was found mainly in white znatter, such as corpus callosum, anterior commissure, and the area around ventricle, such as septal area, corpus striatum. The cells with induced c-fo expression formed cluster and were sindlar to the proliferation of g1ial cells. These results suggest that c-fos expressi0n in the forebrain might be involved in the activation and proliferation of the glial cells at early stage after intraventricular PTG allografting.
出处
《神经解剖学杂志》
CAS
CSCD
北大核心
1998年第1期58-60,共3页
Chinese Journal of Neuroanatomy
