摘要
目的:根据冠心病发病的特点制备复方丹参泡腾性渗透泵片用于其防治,考察其体外释药特性并探明其释药机制。方法:复方丹参药物因含有酚羟基和羧基的酚酸类和三萜皂苷类成分而呈弱酸性,直接加入碳酸氢钠形成泡腾剂,以氯化钠、甘露醇为促渗剂,以HPMC为阻滞剂制得片芯,外包含致孔剂的醋酸纤维素膜制得渗透泵片,利用片芯渗透压的变化研究其释放机制。结果:5种有效成分丹参素、原儿茶醛、人参皂苷Rg1,Rb1,三七皂苷R1以相近的释药规律释药,在渗透压和泡腾作用的共同作用下,药物能够在12 h内以零级速率完全释放药物。结论:成功制得12 h恒速释放的复方丹参泡腾性渗透泵片并阐明其释药机制,为冠心病防治药物和中药新剂型的开发提供思路。
Objective： To prepare effervescent osmotic pump tablet（EOPTs） according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen and to study the mechanism of drug released of that tablets. Method： Since compound Danshen consist of compounds with polyphenolic groups or carboxyl groups, such as phenolic acids, flavonoids, and triterpenoids that they were acidic. EOPTs were prepared from tablet cores which containing NaHCO3 as effervescent, NaCl and manitol as osmotic agents, HPMC as retarding agents coating with CA membrane. And study the mechanism of drug released according to the change of tablet osmotic pressure. Result： The results of in vitro experiments showed that no difference was observed among the profiles of Danshensu, protocatechuic aldehyde, ginsenoside Rg1 , Rb1, notoginsenoside R1 release EOPTs. The drug was completely released from the device with a zero-order release rate over 12 h. Conclusion： EOPTs are Successfully obtained EOPT which the drug is released from the device over 12 h and the release mechanism of EOPTs is explained.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第7期848-851,共4页
China Journal of Chinese Materia Medica
关键词
复方丹参
泡腾性渗透泵片
制备工艺
释药机制
compound danshen
effervescent osmotic pump tablets
preparation
release mechanism
