摘要
目的:观察循环内皮细胞(CEC)和内皮素(ET)在体外循环(CPB)中的变化情况,以及抑肽酶对CEC和ET的影响。方法:20例心脏手术患者,分两组。对照组(n=10),用药组(n=10,CPB前用抑肽酶200万单位,CPB中用200万单位)。在术前、CPB前、CPB 15分钟、CPB 30分钟、CPB 60分钟、术后1天、术后3天、术后5天抽血,测血中CEC和ET。结果:循环内皮细胞对照组和术前比较,CPB前无增高趋势(P>0.05),CPB中明显增加,CPB 30分钟、CPB结束降低(P<0.05),术后1天、3天、5天恢复正常(P>0.05)。用药组变化趋势和对照组相似,但CPB中脱落细胞明显减少,对照组内皮素和术前比较在CPB前有增高趋势,CPB中明显增高(P<0.05),术后1天下降,但仍高于术前。术后3天、术后5天恢复正常(P>0.05)。用药组变化趋势和对照组相似,但CPB中ET增高幅度比对照组轻。结论:CPB血管内皮损伤,大量CEC脱落,同时ET明显增加,抑肽酶对其有明显的缓解作用。
Objective: To observe the changes of circulating endothelial cells (CEC) and endothelin(ET) and the effect of aprotinin on them during open heart surgery. Method:Twenty patients undergoing valve replacement were divided into two groups,control group(n=10) in which and protinin group (n=10), 4000000 unit aprotinin were given during cardiopulmonary bypass (CPB), Blood samples were collected before operation,pre-CPB,15,30 and 60 minute following CPB and 1st, 3rd, 5th day after operation. Result: As compared to pre-CPB in control group,CEC and ET levels increased during CPB and returned the normal after operation. In aprotinin group,the tendency of change was same,but CEC and ET levels were higher in control group than in aprotinin group during CPB. Conclusion:There are endothelial ceils damaging and ET significant increasing during CPB,while aprotinin can ameliorate this situation.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1998年第3期135-137,共3页
Chinese Journal of Anesthesiology
关键词
心肺转流术
抑肽酶
内皮素
血管内皮
Cardiopulmonary bypass Endothelium, vascuiar Cells Endothelins Aprotinin
