摘要
目的:探讨失血性休克病人血中一氧化氮(NO)和乳酸(LA)水平变化的规律及与预后的关系。方法:应用荧光分光光度法和光电比色法测定32例创伤失血性休克病人血中NO和LA浓度的动态变化,并与30例择期手术病人进行对比,同时观察NO和LA与创伤指数及预后的关系。结果:失血休克组NO值明显低于择期手术组(P<0.01),LA值明显高于择期手术组(P<0.01),NO值与创伤指数和LA值呈明显负相关。11例术后并发败血症的病人NO值仍低于正常值。结论:失血休克病人NO降低是导致微循环紊乱和LA升高的主要原因之一,NO水平的变化直接影响病人的预后和转归。因此,失血休克病人在补足血容量的同时,应考虑尽早应用NO供体如硝酸甘油等。
Objective: To investigate the relationship between the plasma concentration of nitric oxide (NO) and prognosis of the hemorrhagic shock. Method:The blood levels of NO and Lactate (LA) were measured with fluorophotometry and colorimetry in 30 hemorrhagic shock patients,and another 30 patients for elective surgery served as a control. Result :Concentration of NO was significantly lower and that of LA was significantly higher in hemorrhagic shock group than that of control group. NO level had a negative correlation with LA level and injury index. NO level in the patients complicated by sepsis were still lower than the control. Conclusion:Decrease of NO level may result in disturbance of microcirculation and increase of LA. So nitroglycerin should be used as early as possible in the hemorrhagic shock patients.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1998年第3期132-134,共3页
Chinese Journal of Anesthesiology
关键词
失血性休克
一氧化氮
乳酸
Nitric Oxide Shock, hemorrhagic Lactate
