摘要
目的探讨c—Met、Survivin在大肠癌中的表达以及二者与肿瘤血管生成的关系。方法选取经病理证实的51例大肠腺癌（直肠癌22例，结肠癌29例；Dukes分期：A期13例，B期14例，C期15例，D期9例；高分化16例，中分化25例，低分化10例，手术切除组织标本。用免疫组化SP法检测c—Met、Survivin的表达及微血管密度（MVD）。结果大肠癌组织中c—Met、Survivin的阳性表达与肿瘤部位无关（P〉0．05），与Dukes分期密切相关（P〈0．05）。大肠癌中c—Met、Survivin均为阳性时MVD值为37±9，单一阳性时的MVD值分别为32±5、26±7，均为阴性时MVD值最小，为14±6。大肠癌组织中c—Met、Survivin的表达呈显著正相关（rs=0．693，P〈0．05）。结论c—Met和Survivin在大肠癌发生、发展、转移过程中起重要作用，并与肿瘤血管生成相关。
Objective To investigate the expression of c - Met, Survivin in colorectal carcinoma and their relationship with angiogenesis and the significance of clinicopathology. Methods Immunohisto- chemical SP method was used to detect the expression of c - Met and Survivin and microvessel density （MVD） in 51 cases of colorectal carcinoma. Results The positive expressions of c - Met and Survivin were correlated with Dukes stage （ P 〈 0.05 ）. In colorectal carcinoma, the MVD was 37 ± 9 when both c - Met and Survivin were positive expression, when both of them were negative expression, the MVD was 14 ± 6. There was a significant correlationship between the expression of c - Met and Survivin （ rs = 0. 693, P 〈 0. 05 ） in colorectal carcinoma. Conclusions e - Met and Survivin play a key role in the development, invasion and metastasis of colorectal carcinoma and correlate with the tumor angiogenesis.
出处
《中国实用医刊》
2009年第7期38-39,41,共3页
Chinese Journal of Practical Medicine
