摘要
目的探讨上海人群中抗原处理相关转运蛋白（ＴＡＰ）与ＩｇＡ肾炎的相关性。方法用ＰＣＲ－ＳＳＯ方法对上海地区８８名正常人及４０名ＩｇＡ肾炎患者ＴＡＰ进行分型。结果在病人组及对照组中共发现３种ＴＡＰ１（ＴＡＰ１Ａ、１Ｂ、１Ｃ）及４种ＴＡＰ２（ＴＡＰ２＊０１０１、＊０１０２、＊０２０１、＊０２０２）等位基因。未发现病人组与对照组之间ＴＡＰ等位基因分布的差异。结论本文结果未能证明ＴＡＰ基因与ＩｇＡ肾炎相关，但不排除未检测的多态位点与ＩｇＡ肾炎关联的可能性。
Owing to their close linkage with the classic HLA classⅡgenes and their function in antigen processing,the possible role of TAP1 and TAP2 in the genetic susceptibility to the autoimmune IgA nephropathy was investigated.TAP1 and TAP2 alleles were determined in 40 IgA nephropathy patients and in 88 normal controls with PCRSSO method.There was no difference in the distrbution in any TAP1 and TAP2 alleles between the patients and the normal controls except for TAP*0202,which was present only in the normal controls.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
1998年第2期128-130,共3页
Chinese Journal of Microbiology and Immunology
基金
国家自然科学基金
