摘要
本文用竞争性放射免疫分析法对64例急性肾炎患儿血浆血栓素A_2(TXA_2)、前列环素(PGI_2)的稳定代谢产物血栓素B_2(TXB_2)、6-酮-前列腺素F_(1α)(6-keto-PGF_(1α))进行了测定。结果显示:急性期患儿TXB_2含量升高,6-keto-PGF_(1α)下降,有高血压及合并症者改变更著;一般轻症患儿于恢复期上述改变恢复正常,而有高血压及并发症者尚不能完全回到正常水平。作者认为急性肾炎有血压升高,并发循环充血、肾功不全者可能与TXA_2、PGI_2改变有一定关系。
Plasma TXB2 and 6-kelo-PGF1α,the stable metabolic products of TXA2 and PGI1,have been serially measured by the method of competitive RIA analysis in the 64 cases of children acute glomerulonephritis. The results obtained clearly revealed that the increase in TXB2 content and the decrease in 6-keto-PGF1α content could be observed during acute stage in the disease,and much more evidently in the patients with hypertension and/or various complications. It also demonstrated that these changes in most of mild cases could restore to normal level in recovery of the disease. though they couldn't completely return normal at all in the cases with hypertension and/or different complications. The changes of TXA2 and PGI2 have possible relationship with hypertension, congestion of circulation and renal insufficiency in acute glomerulonephritis.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
1998年第1期29-30,共2页
Journal of Clinical Pediatrics
