摘要
应用染色体技术和聚合酶链反应方法检测干扰素治疗慢性粒细胞白血病完全缓解后微量残留病28例的疗效。发现治疗后2例Ph'染色体阴转，长期应用干扰素组Ph'染色体阳性率下降，1例bcr／ab1mRNA转为阴性。而短期应用干扰素组无Ph'染色体变化，或bcr／ab1mRNA阴转。按目前我们应用干扰素的剂量、疗程，很难达到有效清除bcr／ab1mRNA阳性细胞的目的。
The curative effect of IFN-α on 28 cases of minimum residual disease (MRD)of chronic myelocylic leukemia (CML) after complete remission was studied by chromosometechnique and PCR. Two cases of ph' chromosome and one case of bcr/abl mRNA negativeconversions were found in the patients treated with IFN-α for 7~12 months. However, nonegative conversion of ph' chromosome or bcr/abl mRNA was found in those treated withIFN-α for 1~6 months. It indicated that bcr/abl mRNA positive cells could not be removedby IFN-α at current dosage and treatment course.
出处
《中国生物制品学杂志》
CAS
CSCD
1998年第1期38-40,共3页
Chinese Journal of Biologicals
关键词
慢性
粒细胞
白血病
微量残留病
Α-干扰素
Chronic myelocytic leukemia Minimum residual disease IFN-α PCR bcr/abl mRNA
