摘要
为了明确开搏通对运动性心肌肥大的作用。本实验采用游泳训练引起的大鼠心肌肥大模型，应用放射免疫及生化等方法对心肌肥大及心脏肾素－血管紧张素系统（Ｒ－Ａ－Ｓ）的变化进行了初步研究。观察到游泳五周时，大鼠心重／体重比值（Ｈ／Ｂｗｔ）显著升高，同时心肌血管紧张素Ⅱ（ＡｎｇⅡ）及心肌血管紧张素转换酶（ＡＣＥ）也明显升高。而服用开搏通的游泳大鼠心肌ＡｎｇⅡ，ＡＣＥ较单纯游泳组低，但心重／体重比值却升高。上述结果提示开搏通能抑制运动所致心肌ＡｎｇⅡ升高，但不能防止运动引起的心肌肥大。
? In order to evaluate the effects of captopril on physiological myocardial hypertrophy induced by swimming training in rat,cardiac angiotensinⅡ (AngⅡ) and angiotensin converting enzyme (ACE) activity were measured by radioimmunoassay and biochemical methods.It was showed that after 5 weeks of swimming,the ratio of heart weight to body weight (H/Bwt),AngⅡ contents and ACE activity increased (P<0.01).In captopril treated group,AngⅡ contents and ACE activity decreased,but H/Bwt increased compared with controls.In conclusion,captopril inhibits cardiac reninangiotensinsystem,but does not prevent cardiac hypertrophy.
出处
《中国应用生理学杂志》
CAS
CSCD
1998年第1期53-55,共3页
Chinese Journal of Applied Physiology
