摘要
目的研究功能性消化不良（ＦＤ）的胆囊排空功能以及西沙必利在此中的作用。方法对９１例ＦＤ患者与３０名健康对照者于空腹和试餐后Ｂ超检查测算胆囊容积、胃面积和胆囊排空率（ＧＢＥＦ）。结果约１／３ＦＤ患者存在胆囊排空功能低下，ＦＤ组ＧＢＥＦ明显低于正常组，且其速度慢，其中ＧＢＥＦｍａｘ分别为６４．８％±１８．２％与７７．７％±１６．１％，Ｐ＜０．００１。ＦＤ组３０例（３３．０％）胆囊排空功能低下者经西沙必利治疗后胆囊排空功能改善，ＧＢＥＦｍａｘ由４９．２％±１９．４％增为６３．３％±１２．４％，Ｐ＜０．０１。治疗后患者症状明显减轻。结论研究表明约１／３的ＦＤ患者胆囊排空功能低下，西沙必利可改善此类患者的症状及胆囊功能。
Objective To study gallbladder emptying in patients with functional dyspepsia (FD) and to know whether cisapride can improve the emptying. Methods Gastric and gallbladder emptying were evaluated by means of real time ultrasonography (RUS) in 91 FD patients and in 30 normal subjects. Serial RUS scans were made at fast and every 20 (first hour) or 30 (second hour) minutes after a liquid meal for 2 hours. Cisapride was given to treat the patients with hypokinetic gallbladder emptying for 1 to 2 weeks. Results (1)Gallbladder ejection fraction (GBEF) in FD patients was much lower and slower than that in normal subjects. The GBEFmax was 64.8%±18.2% in the FD group and 77.7%±16.1% in the normal group ( P <0.001). Thirty patients (33.0%) were considered to have hypokinetic gallbladder emptying as GBEF60' and GBEFmax in these patients were 2 s above the normal group. (2) 25 patients were found with delayed gastric emptying and 11 of them (44.0%) also with hypokinetic gallbladder emptying. The GBEFmax in patients with delayed gastric emptying was slightly lower than those without, but there was no statistical difference between the two groups. (3) Gallbladder emptying was improved in patients with hypokinetic gallbladder emptying treated with cisapride. GBEFmax increased from 49.2%±19.4% to 63.3%±12.4% ( P <0.01). After treatment, the symptoms of the patients relieved. There was no statistical correlation between the improvement of gallbladder and gastric emptying. Conclusion About one third of the patients with functional dyspepsia have hypokinetic gallbladder emptying, and cisapride seems to be useful in improving the emptying.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1998年第1期21-23,共3页
Chinese Journal of Internal Medicine
