摘要
[目的]探讨下肢动脉粥样硬化闭塞症（ASO）与血浆同型半胱氨酸（HCY）水平的关系。【方法】120例动脉粥样硬化闭塞症患者测定血浆HCY、叶酸、维生素B12、并与60例健康对照者相比较。【结果】ASO组的血浆HCY水平和甘油三酯明显高于对照组，而叶酸及维生素B12水平则低于对照组（P〈0．01）。从各项监测指标的相对危险度来看，与ASO有关的因素分别为HCY、叶酸、维生素B12、甘油三酯和收缩压、舒张压。Logistic回归模型检验发现HCY、甘油三酯、高密度脂蛋白和收缩压为ASO的独立致病因素。ASO组和对照组血浆HCY水平与血叶酸、维生素B12水平均呈显著负相关性。【结论】高同型半胱氨酸血症是ASO的独立致病因素，导致高同型半胱氨酸血症的原因可能是血浆内叶酸和维生素B12的降低。
[Objective] To investigate the relationship between atherosclerosis obliterans （ASO）in lower limbs and plasma homocysteine （HCY） level. [Methods] Levels of plasma homocysteine, folate and VitBl2 of 32 ASO patients and 30 healthy subjects were determined. [Results] The mean plasma levels of homocysteine and TG were higher in ASO patients than those in controls, and plasma levels of folate and VitB12 （ P 〈0.01 ） were lower in ASO patients than those in controls. Logistic regress analysis showed that HCY, TG, HDI. and SBP were independent risk factors in ASP. HCY was negatively correlated with folate and VitB12. [Conclusion] Hyperhomocysteinernia is an independent risk factor in ASO. The decrease of plasma folate and VitB12 levels may be the cause of hvperhomocvsteinemia.
出处
《医学临床研究》
CAS
2009年第3期419-421,共3页
Journal of Clinical Research
