摘要
【目的】观察老年胃大部切除手术前后使用胸腺肽α1对病人的T细胞亚群的影响。【方法】35例老年手术病人随机分为对照组（肠内营养组n=20）和研究组（胸腺肽加肠内营养组n=15）。研究组术前1d至术后d6每天给予胸腺肽α1，于术前1d，术后d1、d0分别检测T细胞亚群CD3^＋、CD4^-、CD4^＋／CD8^＋和术前d0，术后d3、d7分别检测血清白介素6（IL6）、肿瘤坏死因子（TNF—α）等急性炎性反应指标。【结果】两组病人术后CD3^＋、CD4^＋、CD4^＋／CD8^＋均有下降及急性炎性反应的发生，但研究组较对照组术后d10的T细胞亚群指标有明显提升（P〈0．05），且研究组病人术后的IL6、TNF-α水平有显著下降。【结论】老年胃大部切除手术病人围手术期应用胸腺肽α1既可提高T细胞亚群水平又能缓解急性相炎性反应。
[Objective]To observe the effect of thymosinα1 on T-cell subsets in senile patients with subtotal gastrectomy. [Methods] Thirty five patients underwent subtotal gastrectomy were randomly divided into control group and study group （thymosinαl plus enteral nutrition group）. Both groups were given isocaloric isonitrogonous enteral nutrition. Thymosinαl plus enteral nutrition group was injected with thymosinal hypodermically form before operation day to postoperative 6th day. All variables of T-cell subsets were measured before operation and on postoperative lth and 10th day. Plasma level of interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α were measured before operation and on postoperative 3th and 7th day. [Results] The percentage of CD3 ^＋ , CD4 ^＋ and the ratio of CD4^＋/CD8^＋ in both groups decreased significantly on the first day after operation. There were significant difference in the percentage of CD3 ^＋ , CD4 ^＋ , CD8^＋ and the ratio of CD4 ^＋ /CD8 ^＋between both groups on postoperative 10th day（ P〉0.05）. In the study group, IL-6 and TNF-α were lower than those in the control group on postoperative 3th and 7th day. [Conclusion] Thymosinal plus enteral nutrition （nutrison fibre） can not only enhance T-cell immune function in senile patients with subtotal gaslrectomy, but also mitigate the inflammatory reaction.
出处
《医学临床研究》
CAS
2009年第3期409-410,413,共3页
Journal of Clinical Research
